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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AKT1
All Species:
36.67
Human Site:
Y263
Identified Species:
73.33
UniProt:
P31749
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P31749
NP_001014431.1
480
55686
Y263
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
Chimpanzee
Pan troglodytes
XP_512662
481
55720
Y265
E
I
V
S
A
L
E
Y
L
H
S
R
D
V
V
Rhesus Macaque
Macaca mulatta
XP_001085623
480
55679
Y263
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
Dog
Lupus familis
XP_548000
481
55446
Y264
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
Cat
Felis silvestris
Mouse
Mus musculus
P31750
480
55604
Y263
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
Rat
Rattus norvegicus
P47196
480
55717
Y263
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513899
512
59226
Y303
E
I
V
S
A
L
D
Y
L
H
S
G
K
I
V
Chicken
Gallus gallus
Q6U1I9
432
48872
D232
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
Frog
Xenopus laevis
Q98TY9
481
56023
Y264
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
Zebra Danio
Brachydanio rerio
Q7ZTW4
433
48964
D233
K
P
E
N
I
L
L
D
S
Q
G
H
I
I
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q8INB9
611
68466
Y379
E
I
I
S
A
L
G
Y
L
H
S
Q
G
I
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17941
541
62181
Y306
E
I
V
L
A
L
G
Y
L
H
R
C
D
I
V
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
81.5
99.5
93.9
N.A.
98.1
98.1
N.A.
73
39.7
93.1
39.3
N.A.
49.5
N.A.
52.5
N.A.
Protein Similarity:
100
92
99.5
95.2
N.A.
98.7
99.1
N.A.
80.4
56.8
96.2
57.5
N.A.
61.7
N.A.
67.8
N.A.
P-Site Identity:
100
73.3
100
100
N.A.
100
100
N.A.
86.6
6.6
100
6.6
N.A.
60
N.A.
60
N.A.
P-Site Similarity:
100
80
100
100
N.A.
100
100
N.A.
86.6
26.6
100
26.6
N.A.
80
N.A.
60
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
84
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% C
% Asp:
0
0
0
0
0
0
59
17
0
0
0
0
17
0
0
% D
% Glu:
84
0
17
0
0
0
9
0
0
0
0
50
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
17
0
0
0
17
9
9
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
84
0
17
0
0
0
% H
% Ile:
0
84
9
0
17
0
0
0
0
0
0
0
17
34
9
% I
% Lys:
17
0
0
0
0
0
0
0
0
0
0
0
59
0
0
% K
% Leu:
0
0
0
9
0
100
17
0
84
0
0
0
0
0
17
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
17
0
0
0
0
0
0
0
0
0
50
0
% N
% Pro:
0
17
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
17
0
9
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
9
9
0
0
0
% R
% Ser:
0
0
0
75
0
0
0
0
17
0
75
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
75
0
0
0
0
0
0
0
0
0
0
17
75
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
84
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _